Antibacterial properties of poly(dimethylsiloxane) surfaces
In a recent study a graphene oxide-catechol hybrid poly(dimethylsiloxane) (PDMS-GO-DMA) surface was prepared. The surface exhibited antibacterial abilities in some degree.
Scientists have prepared the graphene oxide (GO)- a catechol derivative –dopamine methacrylamide monomer (DMA) composite modified poly (dimethylsiloxane) (PDMS) surfaces by π−π stacking of 1-pyrenebutyric acid on the GO and dopamine surface.
PDMS substrates were first oxidised by plasma to transform the Si−CH3 groups on their surfaces into Si−OH groups. Subsequently, aminopropyltriethoxysilane (γ-APS) was immobilised onto the PDMS−OH surface, and 1-pyrenebutyric acid (PA) was then bonded covalently onto the PDMS-γ-APS surfaces by the amidation reaction. Finally, PDMS-GO-DMA surfaces were prepared by modifying GO-DMA composites onto the PDMS-PA surface by π−π stacking between 1-pyrenebutyric acid and GO-DMA.
Various characterisation techniques were used
Various characterisation techniques, including contact angle measurements, attenuated total reflection infrared spectroscopy (ATR-FTIR), and X-ray photoelectron spectroscopy (XPS), were used to ascertain the successful prepared the PDMS-GO-DMA surface.
The antibacterial ability of PDMS-GO-DMA surface was investigated by the classic colony and visible spectrophotometry methods. The results showed that PDMS-GO-DMA surface displayed antibacterial activity against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria compared with native PDMS surface. Furthermore, the biocompatibility of the PDMS-GO-DMA has been studied by culturing the cell lines (HepG2 and A549) on the PDMS-GO-DMA surface which exhibited excellent biocompatibility.
Additionally, the results present possible uses for the PDMS–GO-DMA surface as antibacterial functional surfaces in biomedical microdevices applications.
The study has been published in: Progress in Organic Coatings, Volume 129, April 2019.
Image source: Pixabay.
