Antibacterial activities of N-alkyl imidazolium-based poly(ionic liquid) nanoparticles

Poly(ionic liquid)s (PILs) can self-assemble into polymeric nanoparticles with highly ordered inner structures, which make them potential candidates for antibacterial agents because of their highly concentrated local charges. However, investigation of the antibacterial application of self-assembled PIL nanoparticles has seldom been carried out. In a new study, alkyl imidazolium-based PILs were synthesised via a simple free radical polymerisation and the antibacterial activities of the corresponding PIL nanoparticles were systemically investigated. These obtained PIL nanoparticles exhibited excellent antibacterial activities against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).

Antibacterial effectiveness depending on alkyl chain length

There was a clear dependence of antibacterial efficacy on the alkyl chain length, namely C₁₂ C₁₆ C₁₀ C₈, implying that an optimum alkyl chain length is needed to disrupt the cell membrane. In particular, the contribution of the hydrophobicity effect and charge effect to antibacterial efficacy was evaluated by introducing negatively charged units into PILs. The hydrophobicity effect was shown to be more profound than the charge effect. In addition, the synergistic effect of anions was also found to be dependent on the alkyl chain length of PILs. The proposed structure-antibacterial activity relationship is of vital importance for the structure design and property optimisation of antibacterial polymer nanoparticles.

The study is published in: Polymer Chemistry, 2019, Issue 2.